Cardiovascular diseases are the leading cause of death and disability in the European population and represent a great burden of suffering and costs. When subjected to physiological and pathophysiological forces the blood vessels undergo transformations in wall shape caused by alterations in ECM and cellular composition. This vascular remodelling occurs specifically in small arteries and arterioles, resulting in extreme changes in size and function. Especially in hypertensive or diabetic patients this results in organ dysfunction and progression of vascular disease.
The primary scientific objective of the SmArt network is to determine the molecular mechanisms of cell-matrix and cell-cell interactions in small artery remodeling, aiming to aid in the development of new therapies. The following key areas are in focus: 1) Signalling mechanisms in endothelial and smooth muscle cells, 2) Structural and functional rearrangements in the vessel wall, 3) Role of recruited cells in remodelling.
The major training objective is to provide integrated theoretical and practical multidisciplinary training for young researchers in the complex field of vascular biology. SmArt will promote the careers of young investigators by providing them multidisciplinary expertise in a field of vascular biology with great potential for the future.

Students and supervisors during meeting in Muenster, October 2010

This website will continuously keep you updated on research progress and activities within the SmArt network.

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